The consumption of grapes and raisins presents a potential health threat to dogs. Their toxicity to dogs can cause the animal to develop acute renal failure (the sudden development of kidney failure) with anuria (a lack of urine production). The phenomenon was first identified by the Animal Poison Control Center (APCC), run by the American Society for the Prevention of Cruelty to Animals (ASPCA).  Strangely many dogs can ingest large amounts of grapes with impunity so it is not clear that the observed cases of renal failure following ingestion are due to grapes only. Clinical findings suggest raisin and grape ingestion can be fatal, but the “mechanism of toxicity” is still considered unknown